Trials ongoing and planned as can be found listed online.


In Oxford, UK the RIDD trial has started in 2017, where patients with Dupuytren’s nodules who have not had any other treatment yet will be injected with a drug commonly used for Rheumatoid Arthritis, to see if it stops the progression. Laboratory studies have suggested it is likely to be effective. There are three centra involved in the trial: Livingstone, Oxford and East Grinstead. In this video prof Nanchahal explains a bit about it. Contact via email found on this page.

The DISC trial, Dupuytren’s Interventions: Surgery versus Collagenase, a multicentre randomised trial comparing Limited fasciectomy to collagenase, results and costs. Run over several England based centres. To find your nearest go to this page contact and information.

A trial in York, UK to compare surgery with collagenase injections.

In France a study on Percutaneous Aponeurotomy (=PNF, NA) and in particular the recurrence within two years.


In Liverpool, UK a study on the Benefit Of Night splinting in Dupuytren’s (BOND), expected to run for a few year, to determine the result of splinting versus non splinting at night after Collagenase injections.

In Oslo a comparison between PNF and Collagenase, and 5-year follow up. They are no longer recruiting (Norway).

In Calgary, Canada a study comparing PNF with Collagenase injections, and especially the rate of recurrence up to 5 years.

Two trials in California, USA to determine what level pain relief is needed after hand surgery- Ibuprofen plus paracetamol versus oxycodone and Paracetamol plus codeine versus paracetamol and ibuprofen.

A planned trial in Ontario, Canada to assess the clinical and cost-effectiveness of collagenase compared to PNF (EXTEND).

In Finland a trial is starting to compare Xiapex and LF afterwards if not effective, PNF and LF afterwards if not effective, and LF directly. Short and long term follow up is planned, for mild and moderate Dupuytren’s Contracture.


No trials found


The University of York, UK: a study into the effect of non-surgical therapies for Peyronie’s. This is a literature study only.

A clinical trial in Texas, USA to study the efficacy of Botulinum Toxin Type A in treating Peyronie’s Disease.

A clinical trial in Egypt studying the role of adipose tissue stem cell injection through corpora cavernosa and intra dorsal penile artery in management of erectile dysfunction associated with Peyronie’s disease.