Trials ongoing and planned as can be found listed online.


In Oxford, UK the RIDD¬†trial has started in 2017, where patients with Dupuytren’s nodules who have not had any other treatment yet will be injected with a drug commonly used for Rheumatoid Arthritis, to see if it stops the progression. Laboratory studies have suggested it is likely to be effective. In this video prof Nanchahal explains a bit about it.

Two trials in California, USA to determine what level pain relief is needed after hand surgery- Ibuprofen plus paracetamol versus oxycodone and Paracetamol plus codeine versus paracetamol and ibuprofen.

A trial in York, UK to compare surgery with collagenase injections.

In France a study on Percutaneous Aponeurotomy (=PNF, NA) and in particular the recurrence within two years.

In Oslo a comparison between PNF and Collagenase, and 5-year follow up. They are no longer recruiting (Norway).

In Liverpool, UK a study on the Benefit Of Night splinting in Dupuytren’s (BOND), expected to run for a few year, to determine the result of splinting versus non splinting at night after Collagenase injections.

In Calgary, Canada a study comparing PNF with Collagenase injections, and especially the rate of recurrence up to 5 years.

A planned trial in Ontario, Canada to assess the clinical and cost-effectiveness of collagenase compared to PNF (EXTEND).


No trials found


The University of York, UK: a study into the effect of non-surgical therapies for Peyronie’s. This is a literature study only.

A clinical trial in Texas, USA to study the efficacy of Botulinum Toxin Type A in treating Peyronie’s Disease.

A clinical trial in Egypt studying the role of adipose tissue stem cell injection through corpora cavernosa and intra dorsal penile artery in management of erectile dysfunction associated with Peyronie’s disease.