Dupuytren’s trials ongoing and planned  can be found listed online at the Clinical Trials Register, and at Centrewatch. Peyronie’s trials are found here.


Hand-2, a study starting soon to compare the longterm results of Limited Fasciectomy versus those of Percutaneous Needle Fasciotomy. Prof Tim Davis is the lead investigator, and the study will run in Nottingham and several other locations.

In Paris, France a trial to determine the effectiveness of PNF.

In France a study into the safety and efficacy of second-line surgery after PNF.

In Tampere, Finland a trial to compare treatment strategies for Dupuytren’s.

In Haukeland University Hospital in Norway a trial to determine whether physical therapy improves outcomes after collagenase for Dupuytren’s.

In Belgium, in the ‘Universitair Ziekenhuis Leuven’ a trial is starting led by Prof I Degreef, into the use of Vivisorb at the end of fasiectomy surgery, to see if it will act as functional firebreak and prevent contracture recurrence.

In Calgary, Canada a study comparing PNF with Collagenase injections, and especially the rate of recurrence up to 5 years.

In Ontario, Canada a trial comparing Collagenase with Limited Fasciectomy.

In Quebec,  Canada a trial is being held comparing the effectiveness of two post-fasciectomy rehabilitation protocols in patients with Dupuytren’s Disease. The aim is to evaluate if higher intensity therapy gives better results.

In the Mayo Clinic, Rochester, USA a trial is on the way investigating ‘The effects of Prophylactic Limited Palmar Fasciectomy on surgical outcome and scarring’ , where the theory that removing a thickened pretendinous cord that causes a Trigger Finger gives less complications afterwards than just cutting the cord as is done normally in a surgical procedure for Trigger Finger.

In Minneapolis, Minnesota a trial has started to discover the effect of radiotherapy on disease recurrence after surgical correction of contracture for Dupuytren’s. Dr Dusenbury is the main investigator in the trial.

A trial to monitor the results of radiation therapy for Dupuytren’s has started in Australia, with a possible international involvement in the future. It is known as DEPART  (Dupuytren’s disease: Evaluation of Preventative and Adjuvant Radio Therapy) The trial is run by Genesis Care and Hunter Hand Surgery at Lake Macquarie, Australia. Hand surgeon Dr Brett McClelland and Radiation Oncologist Dr Jarad Martin are the main doctors involved. The trial, which is run as a doubleblind, will evaluate the effect of radiation both in early stage Dupuytren’s and after treatment to correct contracture.


Int the USA in several different locations a trial using collagenase injections for Ledderhose disease has started.


In Miami, Florida USA a trial is about to start (Sept 2020) using PRP for Peyronie’s Disease.

In Assiut, Egypt a trial is due to start November 2017 comparing the outcome of different types of surgery for Peyronie’s.

In Odense, Denmark a trial using ESWT (shockwave) and vacuum devices for Peyronie’s

Dr R. Flannigan of British Columbia University is planning a trial using fractionated carbon dioxide laser for Peyronie’s.

In Miami, Florida a trial to assess treatment response to Xiaflex.


Frozen Shoulder

ANTIFREAZE-F, a trial into the effect of adalimumab injections for frozen shoulder (applied to the capsule of the joint) has started in Birmingham, UK and Lincolnshire, UK. more information on the trial page.