Dupuytren’s trials ongoing and planned  can be found listed online at the Clinical Trials Register, and at Centrewatch. Peyronie’s trials are found here.

EU-wide: 

Study on the Safety and Effectiveness of Vibrio Alginolyticus Collagenase for Patients with Dupuytren’s Contracture

Fidia has developed a novel collagenase and is trialling it  to assess dose, safety and effectiveness. They are not recruiting patients at the moment (September 2026) .

A clinical trial in Denmark:

Study on Percutaneous Needle Fasciotomy with Methylprednisolone Acetate or Saline for Dupuytren’s Contracture in the Finger Joint

This study is recruiting patients (September 2026) 

Australia

Biotech company Connext is a South Korean company developing a recombinant collagenase. Collagenase can be used for injection into the tightening cords which can then become weakened and be broken by the surgeon.

The novel collagenase reached trial stage in patients in 2024. The trials are taking place in Australia.

 

Ledderhose

In the US the STRIDE study is ongoing (2025), which aims to evaluate the effects of collagenase injections for Ledderhose Disease. 

MedStar University in Georgetown, Washington DC has started a trial using Verapamil gel for Ledderhose.